2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

Related Products

PDF 2.76 MB

Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163052
    Ciproquazone
    		Inhibitor
    Ciproquazone (SL-573) is a compound that inhibits prostaglandin biosynthesis. Its relative inhibitory potency is between that of indomethacin and aspirin, and its inhibition of prostaglandin biosynthesis is reversible.
    Ciproquazone
  • HY-117717
    (Rac)-SC-31391
    		Activator
    (Rac)-SC-31391, a prostaglandin analog, is a strong activator of the bladder muscle contractility that enhanced twitch responses elicited by field stimulation in the guinea pig detrusor muscle. (Rac)-SC-31391 contracts human bladder muscle through the activation of PGF2α receptors.
    (Rac)-SC-31391
  • HY-139120
    19(R)-hydroxy Prostaglandin E2
    19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man. It is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor. It has an EC50 value of 200 nM for relaxing cat tracheal rings which express EP2 receptors.
    19(R)-hydroxy Prostaglandin E2
  • HY-160993
    Ciprostene
    		Agonist
    Ciprostene is analog of prostacyclin (PGI2). Ciprostene inhibits adenosine diphosphate-induced platelet aggregation. Ciprostene can be used for research of peripheral vascular disease.
    Ciprostene
  • HY-122399
    Luprostiol
    		Control
    Luprostiol is a prostaglandin analog. Luprostiol can be used to stimulate endocrine changes in animals.
    Luprostiol
  • HY-129934
    Latanoprost ethyl amide
    Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
    Latanoprost ethyl amide
  • HY-14870R
    Selexipag (Standard)
    		Agonist
    Selexipag (Standard) is the analytical standard of Selexipag. This product is intended for research and analytical applications. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
    Selexipag (Standard)
  • HY-16504S
    Treprostinil-13C2,d1 Sodium
    		Agonist
    Treprostinil-13C2-d1 (Sodium) (UT-15-13C2-d1(sodium)) is deuterium and 13C labeled Treprostinil (sodium). Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil-<sup>13</sup>C<sub>2</sub>,d<sub>1</sub> Sodium
  • HY-168802
    9-Keto tafluprost
    9-Keto tafluprost is a derivative of Tafluprost (HY-B0600). Tafluprost is an anti-glaucoma prostaglandin (PG) analog.
    9-Keto tafluprost
  • HY-13448R
    Nedocromil (Standard)
    		Inhibitor
    Nedocromil (Standard) is the analytical standard of Nedocromil. This product is intended for research and analytical applications. Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
    Nedocromil (Standard)
  • HY-114623
    Prostaglandin D2 methyl ester
    		Activator
    Prostaglandin D2 methyl ester is a prodrug form of Prostaglandin D2. Prostaglandin D2 methyl ester binds to the human and mouse PGD2 receptors (DP and CRTH2) with Ki values of 160 nM, 175 nM, 460 nM, and 270 nM for mCRTH2, mDP, hCRTH2, and hDP, respectively.
    Prostaglandin D2 methyl ester
  • HY-114846
    Ro 22-9194
    		Inhibitor
    Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action.
    Ro 22-9194
  • HY-126115R
    15(S)-Latanoprost (Standard)
    		Inhibitor
    15(S)-Latanoprost (Standard) is the analytical standard of 15(S)-Latanoprost. This product is intended for research and analytical applications. 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
    15(S)-Latanoprost (Standard)
  • HY-121720
    L 657925
    		Antagonist
    L 657925 is a potent thromboxane A2 (TXA2) antagonist. L 657925 selectively abolishes ONO 11113-evoked transient increment in [Ca22+].
    L 657925
  • HY-23190
    17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandin F1α
    17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandin F1α (Compound 8) is a saturated prostaglandin analogue. 17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandin F1α has good affinity and receptor selectivity for human prostaglandin F receptor (hFP receptor) witn an EC50 of 85 nM.
    17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandin F1α
  • HY-114841
    ONO 207
    13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 μg/100 g.
    ONO 207
  • HY-108936
    QCC374
    		Agonist
    QCC374 is a selective agonist of IP.
    QCC374
  • HY-129614
    LG 82-4-01
    		Inhibitor
    LG 82-4-01 is a thromboxane (TX) synthetase specific inhibitor, with an IC50 of 1.3 μM.
    LG 82-4-01
  • HY-B0600R
    Tafluprost (Standard)
    		Control
    Tafluprost (Standard) is the analytical standard of Tafluprost. This product is intended for research and analytical applications. Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma[4].
    Tafluprost (Standard)
  • HY-107381R
    (+)-Cloprostenol (Standard)
    		Agonist
    (+)-Cloprostenol (Standard) is the analytical standard of (+)-Cloprostenol. This product is intended for research and analytical applications. (+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
    (+)-Cloprostenol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.